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医药科学

Home 全球十大赌博靠谱的平台 部门 Faculty 帕耶尔·达塔博士

Program Director of 生物制造 and 生物工艺
助理教授
重点:哺乳动物细胞/生物制剂

联系信息
518-694-7483
Payel.datta@cheepezemail.com


议长请求
帕耶尔·达塔博士

Dr. 帕耶尔·达塔获得了博士学位.D. in 生命科学 from Rensselaer Polytechnic Institute (RPI, NY), and her Ph.D. work focused on "Metabolic engineering mammalian cells for the production of value-added-biomolecules". Her postdoctoral work at Albany Medical College focused on developing and utilizing a 3D cell-based assay. Dr. Datta's work at Heparin Applied 研究 Center (start-up Industry-RPI, NY)专注于流程开发, 扩大, 增值产品的技术转移(如.g., enzymes, small molecules, anticoagulant drug heparin, probiotic bacteria). In addition, her 研究 focused on drug efficacy and toxicity studies. Dr. Datta has coauthored a book chapter in the “Encyclopedia of 微生物学”, 在同行评议的期刊上发表了大量文章, 在会议上展示作品, 撰写技术文档. Dr. Datta is highly motivated to harness her expertise and knowledge in teaching, 研究, 劳动力发展.

教育

  • Ph.D., Biology, Rensselaer Polytechnic Institute, Troy, NY, 2013

学院开设的学术课程(2021年至今)

  • 哺乳动物细胞培养
  • 微生物发酵
  • BIO 675G                   Biopharmaceutical Capstone
  • PSC 320/620G         Downstream Processing of Biopharmaceutical Products
  • psc646g调控科学

Workforce Development and Training Programs at CBET (2021-Present)

  • 生物制造原理
  • Mammalian Cell Culture: From cell bank to bioreactor
  • 有ACPHS工作经验
  • FDA mRNA培训计划在ACPHS
  • 修改

目前研究方向
药物安全性和有效性, 基于细胞的筛选平台, 生物制药, 和小分子药物.

药物的目的是预防或治疗疾病. Medicines comprise diverse drug products, including biopharmaceuticals and small-molecule drugs. 生物制药 are biomolecules produced using cell systems. 小分子药物是化学合成的. The journey a medicine/drug takes from its discovery to its approval is highly regulated. The most critical questions include whether the drug is safe and effective. Our 研究 aims to explore the molecular mechanisms of drug action. 具体地说, we employ cell-based screening platforms (2D and 3D cell culture systems) to examine the effects of chemicals and biomolecules on cellular processes, 包括细胞生长, 新陈代谢, 迁移, 信号, 基因表达. Additionally, we aim to investigate the impact of intrinsic and extrinsic factors on drug quality. 通过这些组合方法, the 研究 aims to enhance the understanding of the molecular mechanisms underpinning drug efficacy and potential toxicity.

其他研究兴趣

  • Understanding the biology of industrially relevant cell systems and emerging/alternate chassis
  • 工程细胞生产增值产品
  • Evaluating how intrinsic and extrinsic factors impact product quality, and productivity
  • 增值多糖
  • 单克隆抗体

日报》评论

  • 生物分子
  • 生物技术与生物工程
  • 生物化学过程

本章

评论文章

选定刊物一览表

  • Anti-SARS-CoV-2 activity of rhamnan sulfate from Monostroma nitidum. Y. 歌,P. He, A. L. 罗德里格斯, P. Datta, R. 经脉,J. T. 贝茨,M. Bierdeman C. 陈,我. S. 多迪克,. 张,R. J. 林哈特，海洋药物公司. pubmed.ncbi.nlm.nih.gov / 34940684 /
  • Evaluating heparin products for heparin-induced thrombocytopenia using Surface Plasmon Resonance. F. Zhang, P. Datta, J. S. 多迪克,R. J. 林哈特，《全球十大赌博靠谱的平台》. pubmed.ncbi.nlm.nih.gov / 31705871 /
  • Platelet factor 4 polyanion immune complexes: Heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia. P. Datta, F. 张,我. S. 多迪克,R. J. 林哈特，血栓杂志. pubmed.ncbi.nlm.nih.gov / 34526009 /
  • Complete biosynthesis of a sulfated chondroitin in Escherichia coli. A. 巴蒂尼,. 威廉姆斯,. Awofiranye P. Datta, K. Xia, W. He, K. 弗雷泽,J. S. 多迪克,R. J. 林哈特,M.A.G. Koffas，《全球十大赌博靠谱的平台》. nature.com/articles/s41467 - 021 - 21692 - 5
  • Heparosan chain characterization: sequential depolymerization of E. coli K5 heparosan by a bacterial eliminase heparin lyase III and a bacterial hydrolase heparanase Bp to prepare defined oligomers. P. Datta, L. Yan, A. Awofiranye J. S. 多迪克,R. J. 林哈特，生物技术杂志. pubmed.ncbi.nlm.nih.gov / 33006278 /
  • 益生菌E的高密度发酵. coli Nissle 1917 towards heparosan production, characterization, and modifications. P. Datta, L. Fu, P. Brodfuerer J. S. 多迪克,R. J. 应用微生物学与生物技术. http://pubmed.ncbi.nlm.nih.gov/33481068/
  • Enzymatic generation of highly anticoagulant bovine intestinal heparin. L. Fu, K. Li, D. 森米. Hirakane L. Lin, N. 格罗弗, P. Datta, Y. Yu, J. 赵,F. 张,M. Yalcin,年代. Mousa J. S. 多迪克,R. J. 林哈特，《全球十大赌博靠谱的平台》. pubmed.ncbi.nlm.nih.gov / 28972371 /
  • Expression of enzymes for 3'-phosphoadenosine-5'-phosphosulfate (PAPS) biosynthesis and their preparation for PAPS synthesis and regeneration. P. Datta, L. Fu, W. He, M. A. G. Koffas J. S. 多迪克,R. J. 应用微生物学与生物技术. http://pubmed.ncbi.nlm.nih.gov/32601738/
  • Optimization of bioprocess conditions improves production of a CHO cell-derived, 肝素生物工程. J. Y. Baik, H. Dahodwala E. Oduah L. Talman T. R. Gemmill L. Gasimli, P. Datta, B. 杨,G. Li, F. 张,我. Li, R. J. 林哈特,. M. 坎贝尔,年代. F. Gorfien,年代. T. Sharfstein，生物技术杂志. pubmed.ncbi.nlm.nih.gov / 26037948 /
  • Microarray platform affords improved product analysis in mammalian cell growth studies. P. Datta, L. 梅丽莎,我. Li, N. 米利,E. Schaefer,年代. T. Sharfstein J. S. 多迪克,R. J. 林哈特，生物技术杂志. pubmed.ncbi.nlm.nih.gov / 24227746 /
  • Modulation of heparan sulfate biosynthesis by sodium butyrate in recombinant CHO cells. P. Datta, B. 杨,R. J. 林哈特,年代. T. Sharfstein, Cytotechnology. http://pubmed.ncbi.nlm.nih.gov/24468831/
  • Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site. P. Datta, G. Li, B. Yang, X. Zhao, J. Y. Baik, T. R. Gemmill,年代. T. Sharfstein R. J. 林哈特，生物化学杂志. pubmed.ncbi.nlm.nih.gov / 24247246 /
  • Microscale separation of heparosan, heparan sulfate, and heparin. X. 赵,B. 杨,K. 诈骗, P. Datta, A. 馆,F. 张,R. J. 林哈特，《全球十大赌博靠谱的平台》. pubmed.ncbi.nlm.nih.gov / 23262074 / 
  • Bioengineering murine mastocytoma cells to produce anticoagulant heparin. L. Gasimli C. A. Glass, P. Datta, B. 杨,G. Li, T. R. Gemmill J. Y. Baik,年代. T. Sharfstein J. D. Esko R. J. 林哈特,糖生物学. pubmed.ncbi.nlm.nih.gov / 24326668 /
  • Cell-based microscale isolation of glycosaminoglycans for glycomics study. X. 赵,B. Yang, P. Datta, L. Gasimli F. 张,R. J. 林哈特，《全球十大赌博靠谱的平台》. pubmed.ncbi.nlm.nih.gov / 24068855 /
  • Metabolic engineering of Chinese hamster ovary cells: Towards a 肝素生物工程. J. Y. Baik, L. Gasimli B. Yang, P. Datta, F. 张,C. A. 玻璃、J. D. Esko R. J. 林哈特,年代. T. 谢夫斯坦，代谢工程. pubmed.ncbi.nlm.nih.gov / 22326251 /

摘要和简报精选表

  • Optimization of a bioprocess for production of a non-protein biopharmaceutical: Production of a 肝素生物工程. S. T. Sharfstein J. Y. Baik, L. Talman E. Oduah B. 杨,G. Li, F. Zhang, P. Datta, R. J. 林哈特. Book of Abstracts 247th American Chemical Society National Meeting and Exposition. 2014
  • Cell engineering heparin and heparan sulfate pathway in mammalian cell line. P. Datta, B. Yang, L. Gasimli J. Y.Baik, J. D. Esko R. J. 林哈特,年代. T. Sharfstein. National Meeting of the American Chemical Society, New Orleans, LA. 2013年4月
  • Disaccharide compositional analysis of glycosaminoglycans from biological tissues and cells. B. Yang, A. Weyers J. Y. Baik,年代. T. Sharfstein, P. Datta, H. E. 斯坦斯菲尔德,R. J. 林哈特. Book of Abstracts 244th American Chemical Society Meeting and Exposition. 2012
  • Synthesis of 肝素生物工程 in mammalian cell lines. P. Datta, L. Gasimli X. 赵,B. 杨,我. Y. Baik C. A. 玻璃、J. D. Esko F. 张,年代. T. Sharfstein R. J. 林哈特. Book of Abstracts 244th ACS National Meeting and Exposition. 2012
  • Cell based microscale isolation of glycosaminoglycans for glycomics study. X. 赵,B. Yang, F. Zhang, P. Datta, L. Gasimli R. J. 林哈特. Book of Abstracts 243rd American Chemical Society National Meeting and Exposition. 2012

全球十大赌博靠谱的平台
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